22 NEBRASKA CATTLEMAN April/May 2025 Brief Summary of Full Prescribing Information Active Ingredients: Zinc 60 mg/mL (as zinc oxide); Copper 15 mg/mL (as copper carbonate); Manganese 10 mg/mL (as manganese carbonate); Selenium 5 mg/mL (as sodium selenite) Inactive Ingredients: Edetic acid 399.74 mg/ mL; Sodium hydroxide 106.9 mg/mL; Benzyl alcohol 10.4 mg/mL (as preservative) CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian. INDICATIONS FOR USE To provide a supplemental source of zinc, copper, manganese, and selenium in cattle. Not for use in pregnant cows and heifers during their first trimester because reproductive safety testing has not been done in these animals. Do not use in beef calves less than 2 months of age, dairy calves, and veal calves because safety has not been established. Before using this drug, read package insert for full prescribing information. DOSAGE AND ADMINISTRATION Determine accurate body weights prior to treatment. Administer subcutaneously under the loose skin of the middle of the side of the neck per the following dosages depending on age and bodyweight of the cattle: Cattle up to 1 year, 1 mL/100 lb bodyweight Cattle from 1-2 years, 1 mL/150 lb bodyweight Cattle over 2 years, 1 mL/200 lb bodyweight To be administered as a single dose. The maximum volume per injection site is 7 mL. Use standard aseptic procedures during administration to reduce the risk of injection site abscesses or lesions. Ensure there are at least 4 inches between injection sites for MULTIMIN® 90 (zinc, copper, manganese, and selenium injection) and other injection sites. MULTIMIN® 90 is intended as a single dose product. Allow a minimum of 30 days before considering repeat dosing. Additional zinc, copper, manganese, or selenium products should not be administered at the same time. Use within 28 days of first puncture of the vial and puncture a maximum of 15 times. If more than 15 punctures are anticipated, the use of multi-dosing equipment is recommended. When using a draw-off spike or needle with bore diameter larger than 16 gauge, discard any product remaining in the vial immediately after use. CONTRAINDICATIONS Do not use MULTIMIN® 90 concurrently with other injectable selenium and copper products. Do not use MULTIMIN® 90 concurrently with selenium or copper boluses. WARNINGS AND PRECAUTIONS User Safety Warnings Not for use in humans. Keep out of reach of children. Do not allow children access to used or empty syringes. Wash hands after use. This product is highly concentrated in zinc, copper, manganese, and selenium. Due to a potential risk of zinc, copper, manganese, and selenium toxicity, care should be taken when handling the product to avoid accidental self-injection. Symptoms of exposure to zinc, copper, manganese, and selenium include aches, chills, nausea, vomiting, diarrhea, tachycardia, epigastric pain, tremors, and irritability. In case of accidental self-injection or ingestion, SEEK IMMEDIATE MEDICAL ATTENTION and take the vial with you. To report a suspected adverse drug experience or to obtain a safety data sheet, contact Multimin North America, Inc. at 970-372-2302. ADVERSE REACTIONS Accidental overdose of copper or selenium through misdosing or the use of multiple sources, including the use of injectable products in addition to high dietary levels, can result in adverse events, including death, depression, weakness, ataxia, salivation, and drooling. Animal Safety Warnings and Precautions Selenium and copper are toxic if administered in excess. MULTIMIN® 90 may cause clinical signs associated with copper toxicity or selenium toxicity, including death, if overdosed or used in conjunction with excessive dietary levels of copper and selenium or other selenium or copper products. Additional zinc, copper, manganese, or selenium products should not be administered at the same time. Do not use concurrently with other injectable selenium and copper products. Do not use concurrently with selenium or copper boluses. MULTIMIN® 90 may cause injection site swelling that appears on the day of injection and resolves by 2 days later. MULTIMIN® 90 may cause induration at the injection site that appears the day of injection and may persist for at least 14 days post-injection. These reactions may result in trim loss of edible tissue at slaughter. Do not use in cases of known hypersensitivity to the active ingredients or to any of the excipients. Do not use in emaciated cattle with a body condition score of 1 on a 5-point scale in dairy or 1-3 on a 9-point scale in beef. Do not use during the first trimester of pregnancy because safety has not been evaluated. Do not use in pre-ruminant calves because safety has not been evaluated. TARGET ANIMAL SAFETY Target animal safety was evaluated in cattle less than 10 months of age. Four non-pregnant females and four intact males received saline, 1x, 3x, or 5x the labeled dose for 3 consecutive days. The only treatment-associated findings from the 1x dose group included injection site swelling and a minor, clinically insignificant, dose and time dependent decrease in cholesterol. The treatment-associated findings from the 3x dose group were injection site swelling, a decrease in feed consumption, and a decrease in cholesterol. In the 5x dose group, treatment-associated findings included injection site swelling, a decrease in feed consumption, a decrease in cholesterol, an increase in creatinine kinase, a decrease in calcium, and signs of acute copper toxicity (2 out of 8 animals), including sudden death, depression, weakness, ataxia, salivation, and drooling. Animals in the 5x dose group also had hepatic centrilobular necrosis on necropsy and an increase in serum chemistries associated with liver damage. STORAGE, HANDLING, AND DISPOSAL Store between 15ºC and 30ºC (59ºF and 86ºF) Manufactured for: Multimin North America, Inc., Fort Collins, CO 80528 Approved by FDA under NADA # 141-582 FOI: https://animaldrugsatfda.fda.gov/ adafda/app/search/public/document/ downloadFoi/15347 MULTIMIN® 90 is available in 100 mL and 500 mL vials. Revision date: May 2024 Withdrawal Periods Cattle must not be slaughtered for human food consumption within 14 days of the last treatment. No milk discard time is required when used according to labeling. Animal Health International is a full-service distributor committed to helping beef producers increase production and improve efficiencies. Through our innovative technologies, expert knowledge, expansive product portfolio and fast, customizable delivery options, we help customers manage a sustainable and profitable operation and keep the animals in their care healthy and safe. animalhealthinternational.com 800.854.7664 20AH0030b (11/19)
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