28 NEBRASKA CATTLEMAN September 2024 Brief Summary of Full Prescribing Information Active Ingredients: Zinc 60 mg/mL (as zinc oxide); Copper 15 mg/ mL (as copper carbonate); Manganese 10 mg/mL (as manganese carbonate); Selenium 5 mg/mL (as sodium selenite) Inactive Ingredients: Edetic acid 399.74 mg/mL; Sodium hydroxide 106.9 mg/mL; Benzyl alcohol 10.4 mg/mL (as preservative) CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian. INDICATIONS FOR USE To provide a supplemental source of zinc, copper, manganese, and selenium in cattle. Not for use in pregnant cows and heifers during their first trimester because reproductive safety testing has not been done in these animals. Do not use in beef calves less than 2 months of age, dairy calves, and veal calves because safety has not been established. Before using this drug, read package insert for full prescribing information. DOSAGE AND ADMINISTRATION Determine accurate body weights prior to treatment. Administer subcutaneously under the loose skin of the middle of the side of the neck per the following dosages depending on age and bodyweight of the cattle: Cattle up to 1 year, 1 mL/100 lb bodyweight Cattle from 1-2 years, 1 mL/150 lb bodyweight Cattle over 2 years, 1 mL/200 lb bodyweight To be administered as a single dose. The maximum volume per injection site is 7 mL. Use standard aseptic procedures during administration to reduce the risk of injection site abscesses or lesions. Ensure there are at least 4 inches between injection sites for MULTIMIN® 90 (zinc, copper, manganese, and selenium injection) and other injection sites. MULTIMIN® 90 is intended as a single dose product. Allow a minimum of 30 days before considering repeat dosing. Additional zinc, copper, manganese, or selenium products should not be administered at the same time. Use within 28 days of first puncture of the vial and puncture a maximum of 15 times. If more than 15 punctures are anticipated, the use of multi-dosing equipment is recommended. When using a drawoff spike or needle with bore diameter larger than 16 gauge, discard any product remaining in the vial immediately after use. CONTRAINDICATIONS Do not use MULTIMIN® 90 concurrently with other injectable selenium and copper products. Do not use MULTIMIN® 90 concurrently with selenium or copper boluses. WARNINGS AND PRECAUTIONS User Safety Warnings Not for use in humans. Keep out of reach of children. Do not allow children access to used or empty syringes. Wash hands after use. This product is highly concentrated in zinc, copper, manganese, and selenium. Due to a potential risk of zinc, copper, manganese, and selenium toxicity, care should be taken when handling the product to avoid accidental self-injection. Symptoms of exposure to zinc, copper, manganese, and selenium include aches, chills, nausea, vomiting, diarrhea, tachycardia, epigastric pain, tremors, and irritability. In case of accidental self-injection or ingestion, SEEK IMMEDIATE MEDICAL ATTENTION and take the vial with you. To report a suspected adverse drug experience or to obtain a safety data sheet, contact Multimin North America, Inc. at 970-372-2302. ADVERSE REACTIONS Accidental overdose of copper or selenium through misdosing or the use of multiple sources, including the use of injectable products in addition to high dietary levels, can result in adverse events, including death, depression, weakness, ataxia, salivation, and drooling. Animal Safety Warnings and Precautions Selenium and copper are toxic if administered in excess. MULTIMIN® 90 may cause clinical signs associated with copper toxicity or selenium toxicity, including death, if overdosed or used in conjunction with excessive dietary levels of copper and selenium or other selenium or copper products. Additional zinc, copper, manganese, or selenium products should not be administered at the same time. Do not use concurrently with other injectable selenium and copper products. Do not use concurrently with selenium or copper boluses. MULTIMIN® 90 may cause injection site swelling that appears on the day of injection and resolves by 2 days later. MULTIMIN® 90 may cause induration at the injection site that appears the day of injection and may persist for at least 14 days post-injection. These reactions may result in trim loss of edible tissue at slaughter. Do not use in cases of known hypersensitivity to the active ingredients or to any of the excipients. Do not use in emaciated cattle with a body condition score of 1 on a 5-point scale in dairy or 1-3 on a 9-point scale in beef. Do not use during the first trimester of pregnancy because safety has not been evaluated. Do not use in pre-ruminant calves because safety has not been evaluated. TARGET ANIMAL SAFETY Target animal safety was evaluated in cattle less than 10 months of age. Four non-pregnant females and four intact males received saline, 1x, 3x, or 5x the labeled dose for 3 consecutive days. The only treatment-associated findings from the 1x dose group included injection site swelling and a minor, clinically insignificant, dose and time dependent decrease in cholesterol. The treatment-associated findings from the 3x dose group were injection site swelling, a decrease in feed consumption, and a decrease in cholesterol. In the 5x dose group, treatment-associated findings included injection site swelling, a decrease in feed consumption, a decrease in cholesterol, an increase in creatinine kinase, a decrease in calcium, and signs of acute copper toxicity (2 out of 8 animals), including sudden death, depression, weakness, ataxia, salivation, and drooling. Animals in the 5x dose group also had hepatic centrilobular necrosis on necropsy and an increase in serum chemistries associated with liver damage. STORAGE, HANDLING, AND DISPOSAL Store between 15ºC and 30ºC (59ºF and 86ºF) Manufactured for: Multimin North America, Inc., Fort Collins, CO 80528 Approved by FDA under NADA # 141-582 FOI: https://animaldrugsatfda.fda.gov/adafda/app/search/public/ document/downloadFoi/15347 MULTIMIN® 90 is available in 100 mL and 500 mL vials. Revision date: May 2024 Withdrawal Periods Cattle must not be slaughtered for human food consumption within 14 days of the last treatment. No milk discard time is required when used according to labeling. Eyes on Property Taxes On July 24, 2024, Gov. Pillen issued a proclamation ordering the Nebraska Legislature into a special session, attempting to find a solution for property tax relief. Fewer than 24 hours later, the Unicameral began its first special legislative session since 2021. To summon a special session, the governor must issue an official proclamation notifying all legislators and the public of the purpose, subject and scope designated to this session. Any bills or resolutions considered for referencing, hearings or final votes must be introduced during the first three days of the session. Like the regular session, all bills will receive a hearing, and there is a minimum seven-day threshold that must be met before the body can move to pass legislation. Within the first three days of this special session, 81 bills and 24 constitutional amendments were introduced. Throughout the session, Nebraska Cattlemen (NC) has tracked two main legislative bills considered for property tax relief. Both bills propose that the state of Nebraska fund a majority of K-12 education and work to reduce local levies on property tax. The first, Legislative Bill (LB) 1, adds an estimated $1.5 billion to be used to fund education at the state level. This number would be reached in LB 1 by transferring $560.7 million in Tier II property tax credits and $950.3 million in other General Funds to the Education Future Fund. To offset the property tax reduction, more than 100 current exemptions have been considered for elimination, and “sin taxes” would be increased on products like alcohol and spirits, cigarettes, vaping and hemp. As introduced, the bill would add an excise tax for agricultural and manufacturing equipment and would remove personal property tax on these items. NC policy opposes taxing true business inputs including agricultural machinery and equipment. The second bill, LB 9, places hard caps on levy limits for schools to incrementally decrease from $1.05 to $0.25 by 2033-34. Agricultural land valuations would decrease 30 percent, from 72 percent to 42 percent, and residential valuations would decrease 10 percent, from 96 percent to 86 percent, in the school funding formula. The bill also repurposes current POLICY
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